Pesquisa sobre:
CYTOCHROME-B(5) REDUCTASE
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DeCS
Descritor
Inglês
:
Cytochrome-B(5) Reductase
Descritor
Espanhol
:
Citocromo-B(5) Reductasa
Descritor
Português
:
Citocromo-B(5) Redutase
Categoria:
D08.811.682.608.191.237
D12.776.331.186
Definição
Inglês
:
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to
ALTERNATIVE SPLICING
of a single mRNA. The soluble form is present mainly in
ERYTHROCYTES
and is involved in the reduction of
METHEMOGLOBIN
. The membrane-bound form of the enzyme is found primarily in the
ENDOPLASMIC RETICULUM
and outer mitochondrial membrane, where it participates in the desaturation of
FATTY ACIDS
;
CHOLESTEROL
biosynthesis and drug
metabolism
. A deficiency in the enzyme can result in
METHEMOGLOBINEMIA.
Nota de Indexação
Inglês
:
/defic: consider also
METHEMOGLOBINEMIA
Nota Histórica
Inglês
:
2004; use CYTOCHROME B(5) REDUCTASE (NM) 1980-2003
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
38212
Identificador Único:
D042966
Ocorrência na BVS
:
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